3D reconstruction of coronary bifurcating arteries using coronary angiography data (Master thesis)

Ανδρίκος, Ιωάννης Ο.

This master thesis introduces a novel computational method for three-dimensional (3D) reconstruction of coronary bifurcating vessels utilizing Invasive Coronary Angiography (ICA) data. The novelty of this study is that it unveils the impact of the side branch of the coronary bifurcation anatomy on the blood flow patterns. The surveyed literature suggests that shear stress distribution on the endothelial tissue of the artery could be the base of the definition of a coherent prediction model for plaque development. However, any existing state of the art methodologies omit theses data while computing the three-dimensional model suffering from potential over or underestimation of the shear stress and providing poor plague growth prediction capabilities. Thus, it is essential to generalize the existing mathematical models to the three-dimensional space as well as to the number of the imposed initial boundary conditions to provide a precise blood flow simulation model. In this context, the anatomy and physiology of the cardiovascular system along with an in detail survey of literature on the topics of the heart functionality are initially introduced. Vascular system, blood circulation, pathogenesis, treating strategies, as well as medical imaging procedures are the core concepts that the reader should be familiar with. The second chapter is dedicated on presenting the state of the art methodologies in the field of the 3D reconstruction of the coronary arteries from ICA data along with some mathematical background for blood flow simulation, while the contribution of our work is introduced in chapter 3. A novel methodology for the 3D reconstruction of the coronary bifurcated arteries from ICA data is proposed. The mathematical assumptions for the blood flow simulation as well as the algorithm for the computation of the Fractional Flow Reserve (FFR) are introduced to enforce the validation of our work. Further experimental results are discussed on chapter 4, while chapter 5 concludes asserting the overall methodology, contribution and the impact of our work on the assessment of the Coronary Artery Disease (CAD).
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Πολυτεχνική Σχολή. Τμήμα Μηχανικών Επιστήμης Υλικών
Subject classification: Coronary angiography
Keywords: Coronary angiography
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/29122
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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