Immunohistochemical study of angiogenesis and vasculogenic mimicry in melanocytic tumors of the eye and the periocular area (Doctoral thesis)
Aim. The aim of the present study is to study angiogenesis and vascular mimicry in benign and malignant melanocytic tumors of the eye and the periocular region. Materials and methods. Histological sections from 118 patients were examined. Eighty-eight of the patients had nevi, most of which were conjunctival, while the remaining 30 had malignant melanomas, mostly choroidal. Histological sections were stained either with haematoxylin- eosin or immunohistochemically. Angiogenesis was assessed by studying microvascular density, using antibodies against the endothelial cell markers, CD31 and CD34. Vascular-like channels between neoplastic cells, that were not lined by endothelial cells, and thus were negative for CD31 and CD34, represented areas of vasculogenic mimicry. Results. Angiogenesis was more pronounced in melanomas compared to melanocytic nevi. Angiogenesis was increased in melanomas with high mitotic index and/or epithelioid cell preponderance, compared to melanomas with low mitotic index and/or spindle cell predominance. Vasculogenic mimicry areas were evident in many melanomas and in several nevi. Melanomas with more aggressive histologic features had more extensive areas of vasculogenic mimicry compared to less aggressive tumors. Conclusions. Both angiogenesis and vasculogenic mimicry are more evident in melanomas compared to nevi of the eye and the periocular region. The presence of vasculogenic mimicry in some nevi is a very interesting finding that might have prognostic implications.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Subject classification:||Οφθαλμός -- Όγκοι|
|Appears in Collections:||Διδακτορικές Διατριβές|
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|Δ.Δ. ΣΠΗΛΙΟΠΟΥΛΟΣ ΚΩΝΣΤΑΝΤΙΝΟΣ 2017.pdf||8.59 MB||Adobe PDF||View/Open|
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