Effects of increased body weight and short term weight loss on serum PCSK9 levels (Master thesis)

Γεωργούλα, Μαρία


Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9)is associated with low-density lipoproteins (LDL) catabolism but its serum concentration is not uniformly associated with cardiovascular disease in clinical studies.Obesity is linked with increased cardiovascular risk. Aim and Methods: Aim of this pilot study was to assess possible differences in plasma PCSK9 levels (determined with aquantitative sandwich enzyme immunoassay) between otherwise healthy drug-naïve obese subjects (n= 35, age 4311y) and healthy individuals with normal body weight (n=20, age 356y). Additionally, PCSK9 levels were 71 determined at baseline and after a 3-month weight-loss program in a randomly assigned subgroup of the obese subjects (n=15). Results: Obese subjects were older and had significantly increased body mass index (BMI), waist circumference, total cholesterol, triglycerides, LDL cholesterol (LDL-C), apolipoprotein B and homeostasis model assessment of insulin resistance (HOMA) index levels, as well assignificantly decreased high-density lipoprotein cholesterol(HDL-C) concentration, compared with normal-weight subjects. Plasma PCSK9 levels were significantly increased in obese subjects compared with normal-weight individuals, even after adjustment for age, LDL-C, triglycerides, HDL-C, apolipoprotein A1, apolipoprotein B, apolipoprotein E, glucose, insulin and HOMA index levels (p=0.018). Obese subjects experienced a significant weight loss (from 10922to 10423kg, p<0.01) after the 3-month diet, which was associated with improvement in triglycerideand apolipoprotein E levels. Plasma PCSK9 levels did not significantly change after the 3-month weight-loss program. Conclusions: Plasma PCSK9 levels are increased in obese subjects compared with normal-weight individuals. Short-term weight loss does not change significantly plasma PCSK9 levels.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Subject classification: Παχυσαρκία
Keywords: Μεσογειακή διατροφή,Παχυσαρκία,Απώλεια βάρους,PCSK9,Obesity,Weight loss,Triglycerides,Apolipoprotein
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/28121
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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