Comparison of efficacy of long-acting injectable antipsychotic therapy versus oral treatment in patients with schizophrenia. (Master thesis)

Ευαγγέλου, Γρηγόριος


Schizophrenia is a the most serious psychiatric disorder. Lack of insight often leads to poor compliance and / or discontinuation of medication. Consequence is relapse that usually leads to hospitalization. It is believed that treatment with long acting injectable antipsychotics could reduce relapses. This type of therapy, is provided monthly or fortnightly by the therapist, relieving the patient of the need for daily medication. This study aims to compare the effectiveness of long-acting injectable antipsychotic therapy with oral treatment in patients with schizophrenia. The sample of the study consisted of 40 patients with schizophrenia, who have been hospitalized in recent years in the Department of Psychiatry of the University Hospital of Ioannina. All patients were treated with an oral antipsychotics for years before the initiation to treatment with injectable antipsychotics. There was a significant reduction in patient hospitalization following the systematic administration of injectable antipsychotic drugs. This was observed with all antipsychotic drugs used. The overall reduction in patient hospitalization rates, using long-acting injectable antipsychotics, was 92%, an extremely large and significant percentage. This reduction in patient hospitalization suggests a significant reduction in syptom relapse and a better clinical outcome. The use of injectable antipsychotic drugs by doctors in the future could provide the community with a significant reduction rates in the relapses of people with schizophrenia.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Subject classification: Σχιζοφρένια
Keywords: Schizophrenia,Antipsychotics,Oral antipsychotics
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/28119
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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