The clinical significance of soluble E-cadherin in nonsmall cell lung cancer (Journal article)

Charalabopoulos, K./ Gogali, A./ Dalavaga, Y./ Daskalopoulos, G./ Vassiliou, M./ Bablekos, G./ Karakosta, A./ Constantopoulos, S.


AIM: Aberrant expression of the epithelial transmembrane adhesion molecule E-cadherin (E-cad) has been associated with many human malignancies. In the present study the clinical significance of serum levels of soluble E-cadherin (sE-cad) in newly diagnosed patients with non small cell lung cancer (NSCLC) was investigated. MATERIAL AND METHODS: An enzyme linked immunospecific assay (ELISA) to determine the circulating levels of sE-cad in 20 newly diagnosed patients with NSCLC as well as in 29 healthy volunteers (control group) was used. RESULTS: NSCLC patients exerted increased circulating levels of sE-cad compared with individuals of the control group (p < 0.001). An association was also detected between serum sE-cad levels and the development of distant metastases. On the contrary, no statistically significant correlation could be established with histological type, gender and smoking habits. Patients with increased sE-cad levels at diagnosis had worser outcome, although multivariate analysis failed to demonstrate that sE-cad levels represent an independent prognostic factor of survival. CONCLUSION: Our data suggest that E-cad plays a role in the pathogenesis of NSCLC. sE-cad levels may be further studied as a potential prognostic biomarker.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Aged, 80 and over,Cadherins/*blood,Carcinoma, Non-Small-Cell Lung/*pathology,Female,Humans,Lung Neoplasms/*pathology,Male,Middle Aged,Prognosis,Smoking,Tumor Markers, Biological/blood
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24617
ISSN: 1812-9269
Link: http://www.ncbi.nlm.nih.gov/pubmed/16614715
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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