The effects of cyclic 3',5'-AMP on the lysosomes of newborn rat hepatocytes (Journal article)

Kotoulas, O. B.


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dc.contributor.authorKotoulas, O. B.en
dc.date.accessioned2015-11-24T19:41:45Z-
dc.date.available2015-11-24T19:41:45Z-
dc.identifier.issn0889-1605-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/24528-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectCyclic AMP/*pharmacologyen
dc.subjectLiver/drug effects/*ultrastructureen
dc.subjectLysosomes/drug effects/*ultrastructureen
dc.subjectMicroscopy, Electronen
dc.subjectRatsen
dc.subjectRats, Inbred Strainsen
dc.subjectReference Valuesen
dc.titleThe effects of cyclic 3',5'-AMP on the lysosomes of newborn rat hepatocytesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2839584-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0889160586800209/1-s2.0-S0889160586800209-main.pdf?_tid=875b7e547517e12fb17601a5033afe47&acdnat=1336461315_0882e4e52c1e3e8168ef18be6d81288e-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1986-
heal.abstractCertain effects of cyclic 3',5'-AMP administration on the lysosomes of newborn rat hepatocytes were studied using biochemical assays, electron microscopy, and quantitative morphometry. Cyclic AMP produced accelerations of postnatal hyaloplasmic glycogen breakdown and lysosomal glycogen breakdown, and an increase in activity of the lysosomal enzyme acid alpha-1,4-glucosidase (maltase). Ergotamine, a known antagonist of the effects of cyclic AMP, produced inhibitions of postnatal hyaloplasmic glycogen breakdown and lysosomal glycogen breakdown. Cyclic AMP increased while ergotamine decreased the volume of lysosomes. The results support the postulate that the catabolism of lysosomal glycogen is controlled by those agents that regulate the catabolism of hyaloplasmic glycogen (O. B. Kotoulas and M. J. Phillips, Amer. J. Pathol. (1971) 63, 1-17; O. B. Kotoulas et al., Amer. J. Pathol. (1971) 63, 23-36). Control is mediated by changes in the activity of the lysosomal enzyme acid alpha-1,4-glucosidase. Lysosomes actively participate in the degradation of hepatocellular glycogen.en
heal.journalNameJ Ultrastruct Mol Struct Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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