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https://olympias.lib.uoi.gr/jspui/handle/123456789/24461Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sioka, C. | en |
| dc.contributor.author | Papakonstantinou, S. | en |
| dc.contributor.author | Markoula, S. | en |
| dc.contributor.author | Gkartziou, F. | en |
| dc.contributor.author | Georgiou, A. | en |
| dc.contributor.author | Georgiou, I. | en |
| dc.contributor.author | Pelidou, S. H. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.date.accessioned | 2015-11-24T19:41:14Z | - |
| dc.date.available | 2015-11-24T19:41:14Z | - |
| dc.identifier.issn | 1477-5751 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24461 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Female | en |
| dc.subject | Genotype | en |
| dc.subject | Greece | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Multiple Sclerosis/*genetics | en |
| dc.subject | *Polymorphism, Single Nucleotide | en |
| dc.subject | Receptors, Calcitriol/*genetics | en |
| dc.subject | Regression Analysis | en |
| dc.subject | Taq Polymerase/metabolism | en |
| dc.title | Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1186/1477-5751-10-3 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21545713 | - |
| heal.identifier.secondary | http://www.jnrbm.com/content/pdf/1477-5751-10-3.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been linked to both multiple sclerosis (MS) and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched healthy individuals. Genotyping of Taq-I (rs731236) and Bsm-I (rs1544410) was performed using TaqMan SNP Genotyping Assay. All patients and controls had determination of body mass index (BMI), bone mineral density (BMD) and smoking history. RESULTS: The mean age of patients was 39 +/- 10.5 years compared to 38.7 +/- 10.7 years of the controls (p = 0.86), the BMI was 24.8 +/- 4.2 kg/m2 compared to 25.7 +/- 4.8 kg/m2 of the controls (p = 0.23), the BMD in the lumbar spine 0.981 +/- 0.15 compared to 1.025 +/- 013 of the controls (p = 0.06) and the total hip BMD was 0.875 +/- 0.14 compared to 0.969 +/- 0.12 of the controls (p < 0.001). There were no differences of the Taq-I (TT, CT, CC) and Bsm-I genotypes (GG, GA, AA) and allelic frequencies between MS and control individuals. Multivariate analysis also failed to show any association of the Taq-I and Bsm-I polymorphisms and MS or sex, BMI, BMD and smoking history. CONCLUSIONS: This study suggests that the Taq-I and Bsm-I polymorphisms of the VDR gene are not associated with MS risk, BMI or BMD in the Greek population studied. | en |
| heal.journalName | J Negat Results Biomed | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Sioka-2011-Vitamin D receptor g.pdf | 234.69 kB | Adobe PDF | View/Open Request a copy |
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