The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein (Journal article)

Karetsou, Z./ Martic, G./ Sflomos, G./ Papamarcaki, T.

The oncoprotein SET/TAF-Ibeta is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts directly with the acetyltransferase CREB-binding protein (CBP) and enhances the transactivation potential of the transcription coactivator. Our data suggest that the histone chaperone SET regulates the CBP-mediated transcription and may indicate a general principle by which transcriptional regulators cooperate with histone chaperones for gene activation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Biotinylation,CREB-Binding Protein,Cell Cycle,Chromosomal Proteins, Non-Histone/*chemistry/metabolism,Fluorescent Antibody Technique, Indirect,Glutathione Transferase/metabolism,HeLa Cells,Histone Chaperones,Histones/*chemistry,Humans,Immunoprecipitation,Microscopy, Confocal,Molecular Chaperones/chemistry,Mutation,Nuclear Proteins/*chemistry,Plasmids/metabolism,Protein Binding,Recombinant Proteins/chemistry,Trans-Activators/*chemistry,Transcription Factors/*chemistry/metabolism,Transcription, Genetic,Transcriptional Activation
ISSN: 0006-291X
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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