(99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation index (Journal article)
Fotopoulos, A. D./ Alexiou, G. A./ Goussia, A./ Papadopoulos, A./ Kyritsis, A. P./ Polyzoidis, K. S./ Voulgaris, S./ Tsiouris, S.
Meningiomas account for about 30% of all intracranial tumors. Evaluation of their proliferation rate is useful for assessing their biological behavior. We evaluated prospectively whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake in meningiomas correlates with cellular proliferative activity and with tumor grade. We prospectively studied 18 meningioma cases. Brain single-photon emission computed tomography (SPECT) by (99m)Tc-TF was performed within a week prior to surgical excision. In the excised tumor specimens we assessed Ki-67 antigen expression. 14 of 18 patients had benign meningiomas, while the remaining four had anaplastic meningiomas. A significant correlation was found between both (99m)Tc-TF uptake and tumor grade (r = 0.722, P = 0.001) and between (99m)Tc-TF uptake and Ki-67 expression (r = 0.930, P < 0.001). There was a significant correlation between the intensity of tracer uptake and tumor recurrence at 1 year postoperative (r = 0.574, P = 0.02). This pilot study implies that (99m)Tc-TF brain SPECT could prove useful in differentiating benign from anaplastic meningiomas and is a potential indicator of their proliferative activity.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||Aged,Brain/metabolism/*radionuclide imaging,Cell Proliferation,Female,Humans,Ki-67 Antigen/metabolism,Magnetic Resonance Imaging,Male,Meningeal Neoplasms/pathology/*radionuclide imaging,Meningioma/pathology/*radionuclide imaging,Middle Aged,Retrospective Studies,Statistics as Topic,Technetium Tc 99m Sestamibi/*diagnostic use,*Tomography, Emission-Computed, Single-Photon|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
Files in This Item:
|Fotopoulos-2008-(99m)Tc-Tetrofosmin.pdf||260.59 kB||Adobe PDF||View/Open Request a copy|
Please use this identifier to cite or link to this item:This item is a favorite for 0 people.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.