A case of Brucella spondylitis in a patient with psoriatic arthritis receiving infliximab (Journal article)

Papagoras, C. E./ Argyropoulou, M. I./ Voulgari, P. V./ Vrabie, I./ Zikou, A. K./ Drosos, A. A.

A 69-year-old woman with psoriatic arthritis treated with infliximab presented with low back pain of recent onset and fever. Serological, microbiological and imaging studies revealed Brucella spondylitis at the L5-S1 level. Immunosuppressive therapy was suspended and antibiotic therapy including doxycycline and rifampicin was administered for six months. The patient responded adequately with clinical and laboratory improvement and a considerable remission of spondylitis on repeat magnetic resonance imaging scan. The pathophysiology of tumor necrosis factor (TNF) alpha in Brucellosis and the role of anti-TNFalpha therapy are discussed.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Anti-Bacterial Agents/therapeutic use,Antibodies, Monoclonal/*adverse effects,Arthritis, Psoriatic/*drug therapy,Brucellosis/diagnosis/drug therapy/*immunology,Doxycycline/therapeutic use,Drug Therapy, Combination,Female,Humans,Immunity, Innate/immunology,Rifampin/therapeutic use,Spondylitis/*microbiology,Tumor Necrosis Factor-alpha/*antagonists & inhibitors/immunology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24400
ISSN: 0392-856X
Link: http://www.ncbi.nlm.nih.gov/pubmed/19327241
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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