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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24323
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dc.contributor.authorKanoria, S.en
dc.contributor.authorGlantzounis, G.en
dc.contributor.authorJalan, R.en
dc.contributor.authorDavies, N. A.en
dc.contributor.authorSeifalian, A. M.en
dc.contributor.authorWilliams, R.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T19:40:15Z-
dc.date.available2015-11-24T19:40:15Z-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24323-
dc.rightsDefault Licence-
dc.subjectAlanine Transaminase/blooden
dc.subjectAnimalsen
dc.subjectAspartate Aminotransferases/blooden
dc.subjectBlood Pressureen
dc.subjectDisease Models, Animalen
dc.subjectKineticsen
dc.subjectL-Lactate Dehydrogenase/blooden
dc.subject*Liver Circulationen
dc.subjectOxygen/blooden
dc.subjectRabbitsen
dc.subjectReperfusion Injury/enzymology/*physiopathologyen
dc.subjectTime Factorsen
dc.titleA model to study total hepatic ischemia-reperfusion injuryen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.transproceed.2004.10.031-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15621096-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0041134504011972/1-s2.0-S0041134504011972-main.pdf?_tid=4affcdb7f891cb36ec11835fc9a3dfe7&acdnat=1333626340_1f4056c21374cd3b58080d05b3a1f500-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractBACKGROUND: Most experimental animal models for studying hepatic ischemia-reperfusion injury (IRI) involve partial or segmental ischemia of the liver or a portocaval shunt procedure to avoid mesenteric congestion. However, these do not reflect the global ischemia that occurs during liver transplantation. A rabbit model of total hepatic ischemia without a portocaval shunt is described. METHODS: Twenty male New Zealand white rabbits (3.5 +/- 0.3 kg) were allocated to four groups: group 1 (n = 5), sham-operated; group 2 (n = 5), 20-minute total hepatic ischemia; group 3 (n = 5), 25-minute total hepatic ischemia; and group 4 (n = 5), 30-minute total hepatic ischemia. Total hepatic ischemia was induced by occluding the portal inflow vessels (portal vein and artery) with an atraumatic vascular loop and were measurements taken for 2 hours during reperfusion. RESULTS: A total hepatic ischemia of 30 minutes caused severe liver injury resulting in cardiac arrest at 2 hours of reperfusion in all five animals due to metabolic acidosis. Twenty minutes of total ischemia was tolerated and did not produce significant liver injury. Twenty-five minutes of total ischemia was tolerated but at 2 hours of reperfusion, resulted in significant liver injury (68 +/- 41, 283.0 +/- 20.5, and 835.2 +/- 52.7 U/L) compared with the sham-operated group (serum ALT, 25.4 +/- 2.7; serum AST, 47.4 +/- 3.0; serum LDH, 307.6 +/- 44.4 U/L; P < .003). CONCLUSIONS: Rabbits can tolerate 25 minutes of total hepatic ischemia without a portosystemic shunt. This 25-minute ischemia model simulates operative conditions during liver transplantation and will be valuable in studies modulating IRI.en
heal.journalNameTransplant Procen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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