A new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevi (Journal article)

Batistatou, A./ Zioga, A./ Panelos, J./ Massi, D./ Agnantis, N. J./ Charalabopoulos, K.

Common melanocytic nevi are ubiquitous lesions which in some cases constitute a risk factor for the development of melanoma. To date, despite long term research there are no known molecular hallmarks for nevus development. We have observed that common acquired nevi excised from the same individual share remarkable similarity in their microscopic appearance and in the immunohistochemical expression of E-cadherin. Based on these observations, we hypothesize that all melanocytes are genetically similar in the same individual and changes predisposing to neoplasia are a global melanocytic event characteristic for each person and propose a microgenomics/proteomics approach to test this hypothesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Cadherins/biosynthesis,Dysplastic Nevus Syndrome/pathology,Female,Humans,Immunohistochemistry/methods,Male,Melanocytes/*metabolism,Melanoma/*etiology/pathology,Middle Aged,Neoplasms/*pathology,Nevus, Pigmented/*pathology,Precancerous Conditions/pathology,Risk Factors,Skin Neoplasms/*etiology/pathology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/24310
ISSN: 0306-9877
Link: http://www.ncbi.nlm.nih.gov/pubmed/17459602
http://ac.els-cdn.com/S0306987707002034/1-s2.0-S0306987707002034-main.pdf?_tid=2576a3d221faebc1db6e907cdd4f2750&acdnat=1333346693_5307a0f29aa4f1f949305e4383cc82cb
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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