A quantitative description of the insulin-induced ultrastructural changes in newborn rat hepatocytes (Journal article)

Maintas, D. B./ Kotoulas, O. B./ Kotoulas, A. O.


The effects of insulin on the ultrastructure of newborn rat hepatocytes were systematically quantified at satisfactory statistical significance. Insulin prevented the normal postnatal increase in the total volume of lysosomes and the breakdown of glycogen inside these organelles. The lysosomal glycogen-hydrolysing enzyme, acid alpha 1,4 glucosidase was inhibited by the hormone. Insulin also prevented the normal postnatal increase in the total volume of peroxisomes, especially of the crystalloid core-devoid type. The hormone produced an increase in the area of cell membrane, due to the formation of many irregular folds of the cell surface. These results constitute good evidence for participation of lysosomes and peroxisomes in the overall glycogen degradation and or gluconeogenesis in the newborn rat hepatocytes.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Female,Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors/metabolism,Insulin/*physiology,Liver/metabolism/*ultrastructure,Liver Glycogen/metabolism,Lysosomes/metabolism/ultrastructure,Microscopy, Electron,Mitochondria, Liver/enzymology/ultrastructure,Pregnancy,Rats,Rats, Wistar
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24257
ISSN: 0213-3911
Link: http://www.ncbi.nlm.nih.gov/pubmed/8490249
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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