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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24245
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dc.contributor.authorBaxter, J. D.en
dc.contributor.authorMayers, D. L.en
dc.contributor.authorWentworth, D. N.en
dc.contributor.authorNeaton, J. D.en
dc.contributor.authorHoover, M. L.en
dc.contributor.authorWinters, M. A.en
dc.contributor.authorMannheimer, S. B.en
dc.contributor.authorThompson, M. A.en
dc.contributor.authorAbrams, D. I.en
dc.contributor.authorBrizz, B. J.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorMerigan, T. C.en
dc.date.accessioned2015-11-24T19:39:25Z-
dc.date.available2015-11-24T19:39:25Z-
dc.identifier.issn0269-9370-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24245-
dc.rightsDefault Licence-
dc.subjectAcquired Immunodeficiency Syndrome/blood/*drug therapy/immunologyen
dc.subjectAdulten
dc.subjectAnti-HIV Agents/*therapeutic useen
dc.subjectCD4 Lymphocyte Counten
dc.subjectDrug Resistance, Microbial/*geneticsen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectHIV Infections/blood/*drug therapy/immunologyen
dc.subjectHIV Protease Inhibitors/therapeutic useen
dc.subjectHIV Reverse Transcriptase/geneticsen
dc.subjectHIV-1/*genetics/isolation & purificationen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMutationen
dc.subjectRNA, Viral/blood/geneticsen
dc.subjectViral Loaden
dc.titleA randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDSen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10894268-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractOBJECTIVE: To determine the short-term effects of using genotypic antiretroviral resistance testing (GART) with expert advice in the management of patients failing on a protease inhibitor and two nucleoside reverse transcriptase inhibitors. DESIGN: Prospective randomized controlled trial. SETTING: Multicenter community-based clinical trials network. PATIENTS: One-hundred and fifty-three HIV-infected adults with a threefold or greater rise in plasma HIV-1 RNA on at least 16 weeks of combination antiretroviral therapy. INTERVENTIONS: Randomization was either to a GART group, where genotype interpretation and suggested regimens were provided to clinicians, or to a no-GART group, where treatment choices were made without such input. MAIN OUTCOMES MEASURES: Plasma HIV-1 RNA levels and CD4 cell counts were measured at 4, 8, and 12 weeks following randomization. The primary endpoint was change in HIV-1 RNA levels from baseline to the average of the 4 and 8 week levels. RESULTS: The average baseline CD4 cell count was 230 x 10(6) cells/l and the median HIV-1 RNA was 28,085 copies/ml. At entry, 82 patients were failing on regimens containing indinavir, 51 on nelfinavir, 11 on ritonavir, and nine on saquinavir. HIV-1 RNA, averaged at 4 and 8 weeks, decreased by 1.19 log10 for the 78 GART patients and -0.61 log10 for the 75 no-GART patients (treatment difference: -0.53 log, 95% confidence interval, -0.77 to -0.29; P = 0.00001). Overall, the best virologic responses occurred in patients who received three or more drugs to which their HIV-1 appeared to be susceptible. CONCLUSION: In patients failing triple drug therapy, GART with expert advice was superior to no-GART as measured by short-term viral load responses.en
heal.journalNameAIDSen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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