Abatacept: a biologic immune modulator for rheumatoid arthritis (Journal article)

Papagoras, C./ Drosos, A. A.


INTRODUCTION: Abatacept is a biologic drug that belongs to the class of T-cell co-stimulation modulators and is used for the treatment of rheumatoid arthritis (RA). AREAS COVERED: This article covers major randomized clinical trials and meta-analyses concerning abatacept in the treatment of RA, as identified in a Pubmed search. Scientific meeting abstracts describing long-term extension data of the identified trials are also included. Efficacy outcomes and the safety profile are the focus of this evaluation. EXPERT OPINION: Abatacept in combination with methotrexate (MTX) or other synthetic disease-modifying anti-rheumatic drugs (DMARD) has been proven effective for the treatment of RA in different groups of patients: with early RA and no prior exposure to DMARD; with DMARD-resistant RA; and with RA not responding to TNF-alpha-blocking agents. Significant reductions of disease activity are achieved, with 1-year remission rates reaching up to 41% of DMARD-naive patients with early RA receiving a combination of abatacept plus MTX. Abatacept treatment has been shown to improve function and quality of life and to suppress radiographic progression. No major safety issues have emerged during clinical trials and long-term extensions. Therefore, abatacept is a drug with a favorable efficacy and safety profile, which may offer substantial benefits to RA patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antirheumatic Agents/*therapeutic use,Arthritis, Rheumatoid/immunology/*therapy,Humans,Immunoconjugates/*therapeutic use,*Immunotherapy,Meta-Analysis as Topic,Randomized Controlled Trials as Topic,Treatment Outcome
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24179
ISSN: 1744-7682
Link: http://www.ncbi.nlm.nih.gov/pubmed/21649536
http://informahealthcare.com/doi/abs/10.1517/14712598.2011.592825
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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