Acid-base and electrolyte disturbances in patients with hypercalcemia (Journal article)

Milionis, H. J./ Rizos, E./ Liamis, G./ Nikas, S./ Siamopoulos, K. C./ Elisaf, M. S.

BACKGROUND: In the present study, we analyzed acid-base and electrolyte disturbances in hypercalcemic patients to determine the principal causes of hypercalcemia. METHODS: We studied a total of 76 hypercalcemic patients and 91 healthy individuals. Acid-base and electrolyte parameters were determined before any therapeutic intervention. RESULTS: Hyperparathyroidism and neoplasias were the most common causes of hypercalcemia. Hypercalcemic patients had increased serum urea and creatinine levels, a higher urea/creatinine ratio, and a higher rate of acid-base disorders, but lower serum albumin, potassium, chloride, phosphorus, and magnesium concentrations than those found in the control subjects. Notably, significant differences in acid-base balance and electrolyte concentrations were evident between patients with hyperparathyroidism and patients with cancer. CONCLUSIONS: Primary hyperparathyroidism and neoplasia are the most common causes of hypercalcemia. A wide array of concurrent acid-base and electrolyte disorders may be evident in hypercalcemic patients. Differences in these laboratory parameters are helpful in diagnostic workup.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acid-Base Imbalance/epidemiology/*etiology,Adult,Aged,Aged, 80 and over,Case-Control Studies,Female,Greece/epidemiology,Humans,Hypercalcemia/*complications/etiology,Hyperparathyroidism/complications/diagnosis,Male,Middle Aged,Neoplasms/complications/diagnosis,Statistics, Nonparametric,Water-Electrolyte Imbalance/epidemiology/*etiology
ISSN: 0038-4348
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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