Acute renal dysfunction associated with selective COX-2 inhibitor therapy (Journal article)

Papaioannides, D./ Bouropoulos, C./ Sinapides, D./ Korantzopoulos, P./ Akritidis, N.

The recent release of the selective cyclooxygenase-2 (COX-2) enzyme inhibitors for the treatment of various inflammatory disorders and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects. The nephrotoxic effect of selective COX-2 inhibitors has not yet been firmly established. We report a case of reversible acute renal failure due to rofecoxib treatment in an elderly patient with several risk factors associated with traditional nonselective nonsteroidal anti-inflammatory drug (NSAID)-related nephrotoxicity. It is prudent to approach therapy with selective COX-2 inhibitors cautiously and in a fashion similar to traditional NSAID therapy for patients with risk factors that induce prostaglandin-dependent renal function.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acute Kidney Injury/*chemically induced,Aged,Cyclooxygenase 2,Cyclooxygenase 2 Inhibitors,Cyclooxygenase Inhibitors/*adverse effects,Humans,Isoenzymes/*antagonists & inhibitors,Kidney/drug effects,Lactones/*adverse effects,Male,Membrane Proteins,Prostaglandin-Endoperoxide Synthases,Sulfones
ISSN: 0301-1623
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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