Acute renal dysfunction associated with selective COX-2 inhibitor therapy (Journal article)

Papaioannides, D./ Bouropoulos, C./ Sinapides, D./ Korantzopoulos, P./ Akritidis, N.

The recent release of the selective cyclooxygenase-2 (COX-2) enzyme inhibitors for the treatment of various inflammatory disorders and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects. The nephrotoxic effect of selective COX-2 inhibitors has not yet been firmly established. We report a case of reversible acute renal failure due to rofecoxib treatment in an elderly patient with several risk factors associated with traditional nonselective nonsteroidal anti-inflammatory drug (NSAID)-related nephrotoxicity. It is prudent to approach therapy with selective COX-2 inhibitors cautiously and in a fashion similar to traditional NSAID therapy for patients with risk factors that induce prostaglandin-dependent renal function.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acute Kidney Injury/*chemically induced,Aged,Cyclooxygenase 2,Cyclooxygenase 2 Inhibitors,Cyclooxygenase Inhibitors/*adverse effects,Humans,Isoenzymes/*antagonists & inhibitors,Kidney/drug effects,Lactones/*adverse effects,Male,Membrane Proteins,Prostaglandin-Endoperoxide Synthases,Sulfones
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/24084
ISSN: 0301-1623
Link: http://www.ncbi.nlm.nih.gov/pubmed/12452607
http://www.springerlink.com/content/q0n2wq9332203066/fulltext.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Papaioannides-2001-Acute renal dysfunct.pdf44.75 kBAdobe PDFView/Open    Request a copy


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/24084
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.