Volume and flow dependence of respiratory mechanics in mechanically ventilated COPD patients (Journal article)

Vassiliou, M. P./ Amygdalou, A./ Psarakis, C. J./ Dalavanga, Y./ Vassiliou, P. M./ Mandragos, K. E./ Constantopoulos, S. H./ Behrakis, P. K.


Volume and flow dependencies of respiratory mechanics are examined in 10 COPD patients under mechanical ventilation (MV) at 3 levels of externally applied PEEP (PEEPe). Airways pressure (Paw), flow (V') and volume (V) data are analyzed according to (1) the linear and (2) a non-linear model, accounting for volume dependence of elastance and for flow and volume dependence of resistance. The models' fitness to data is assessed by the regression errors. Non-linear modelling fits significantly better to data, while the difference of fitness decreases with PEEPe. Linear mechanics are not significantly different between the 3 levels of PEEPe. A positive volume dependence of elastance observed at 0, decreases at 5 and increases again at 10 hPa of PEEPe. A seriously negative volume dependence of resistance at 0 turned to positive with PEEPe. These dependencies of respiratory mechanics during COPD under MV, show that the present non-linear respiratory mechanical monitoring may help for better and less risky adjustment of PEEPe.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Female,Humans,Male,Middle Aged,*Models, Biological,Positive-Pressure Respiration/methods,Pulmonary Disease, Chronic Obstructive/*physiopathology/therapy,Pulmonary Ventilation/*physiology,*Respiration, Artificial
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24053
ISSN: 1569-9048
Link: http://www.ncbi.nlm.nih.gov/pubmed/12706068
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Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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