alpha-Mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surface (Journal article)

Belmonte, S. A./ Challa, A./ Gutierrez, L. S./ Bertini, F./ Sosa, M. A.


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dc.contributor.authorBelmonte, S. A.en
dc.contributor.authorChalla, A.en
dc.contributor.authorGutierrez, L. S.en
dc.contributor.authorBertini, F.en
dc.contributor.authorSosa, M. A.en
dc.date.accessioned2015-11-24T19:36:59Z-
dc.date.available2015-11-24T19:36:59Z-
dc.identifier.issn0105-6263-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/23972-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBody Fluids/enzymologyen
dc.subjectEpididymis/enzymologyen
dc.subjectHydrogen-Ion Concentrationen
dc.subjectLigandsen
dc.subjectMaleen
dc.subjectMannosidases/*metabolismen
dc.subjectRatsen
dc.subjectReceptors, Cytoplasmic and Nuclear/*metabolismen
dc.subjectSpermatozoa/*metabolismen
dc.subjectalpha-Mannosidaseen
dc.titlealpha-Mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surfaceen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9805243-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractThis study demonstrates that alpha-mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surface. This enzyme was bound to intact epididymal spermatozoa with high affinity and in saturable form, and the binding was inhibited by mannose-6-phosphate but not by phosphorylated derivatives of fructose. Treatment of the enzyme with sodium periodate inhibited the binding of alpha-mannosidase, confirming that a carbohydrate residue is involved in the interaction with spermatozoa. Evidence is also presented that the cation-independent phosphomannosyl receptors are responsible for the interaction with alpha-mannosidase. These findings suggest a new role for extracellular transport mediated by the mannose-6-phosphate receptor.en
heal.journalNameInt J Androlen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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