Amplification and co-regulators of androgen receptor gene in prostate cancer (Journal article)

Golias, Ch/ Iliadis, I./ Peschos, D./ Charalabopoulos, K.

Prostate cancer is the second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group of steroid hormones that include testosterone and its more active metabolite dihydrotestoste-rone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: *Gene Expression Regulation, Neoplastic,Humans,Male,Mutation,Prostatic Neoplasms/*genetics/immunology/*metabolism/physiopathology,Receptors, Androgen/*genetics/immunology/*metabolism
ISSN: 1812-9269
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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