Amplification and co-regulators of androgen receptor gene in prostate cancer (Journal article)
Golias, Ch/ Iliadis, I./ Peschos, D./ Charalabopoulos, K.
Prostate cancer is the second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group of steroid hormones that include testosterone and its more active metabolite dihydrotestoste-rone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed.
Institution and School/Department of submitter: | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής |
Keywords: | *Gene Expression Regulation, Neoplastic,Humans,Male,Mutation,Prostatic Neoplasms/*genetics/immunology/*metabolism/physiopathology,Receptors, Androgen/*genetics/immunology/*metabolism |
URI: | https://olympias.lib.uoi.gr/jspui/handle/123456789/23928 |
ISSN: | 1812-9269 |
Link: | http://www.ncbi.nlm.nih.gov/pubmed/19300409 |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) |
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Peschos-2009-amplification and co regulators.pdf | 828.36 kB | Adobe PDF | View/Open Request a copy |
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https://olympias.lib.uoi.gr/jspui/handle/123456789/23928
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