An electron microscopic and biochemical study of the effects of cyclic 3', 5'-AMP, ergotamine or propranolol on the lysosomes of newborn rat hepatocytes (Journal article)

Kotoulas, A. O./ Kotoulas, O. B./ Kalamidas, S.

The effects of cyclic 3',5'-AMP, ergotamine or propranolol on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Cyclic AMP enhanced the normal postnatal rise in the glycogen-hydrolysing activity of acid alpha 1, 4 glucosidase but had no effect on the maltose-hydrolysing activity of the enzyme. The results suggest that these activities may be due to different enzymes. Propranolol prevented the postnatal increase in the glycogen-hydrolysing activity of acid glucosidase and the breakdown of lysosomal glycogen, indicating that these phenomena represent beta-adrenergic functions in newborn rats. Ergotamine also inhibited the postnatal increase in this activity and the lysosomal glycogen mobilization. A reasonable explanation for these results is that ergotamine interferes with the action or formation of cyclic AMP.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Autophagy,Cyclic AMP/antagonists & inhibitors/*pharmacology,Ergotamine/*pharmacology,Glycogen/metabolism,Liver/*drug effects/ultrastructure,Lysosomes/*drug effects/ultrastructure,Maltose/metabolism,Propranolol/*pharmacology,Rats,Rats, Inbred Strains,Vacuoles/drug effects/ultrastructure,alpha-Glucosidases/drug effects
ISSN: 0213-3911
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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