Repository of UOI "Olympias"

Anticoagulant drugs: what is new? (Journal article)

Kei, A./ Florentin, M./ Elisaf, M. S./ Liberopoulos, E.

Heparins and vitamin K antagonists have been the cornerstones of anticoagulation treatment for several decades. Despite their effectiveness, these agents have limitations which can include food and drug interactions and the need for monitoring. It follows that there is a need for new anticoagulants. There are numerous promising agents at various stages of evaluation. Those in the most advanced stages of development are the oral factor Xa and the thrombin inhibitors, which are the focus of this review.