Antiplatelet antibodies in patients with chronic viral hepatitis receiving interferon-alpha (Journal article)

Christodoulou, D./ Christou, L./ Zervou, E./ Katsanos, K./ Kitsanou, M./ Tsianos, E. V.

BACKGROUND/AIMS: The aim of this study was to investigate the possible role of interferon-alpha in the development of antiplatelet IgG antibodies in patients with chronic viral hepatitis B or C. METHODOLOGY: Ninety-one consecutive patients with chronic viral hepatitis (51 with chronic hepatitis B and 40 with chronic hepatitis C) were investigated for the presence of antiplatelet IgG antibodies in their serum immediately prior to IFN-alpha therapy and after six months of therapy. The method used was the solid phase red cell adherence test (Immucor, Norcross, USA), which is a sensitive tracer of antiplatelet antibodies. Some of the results were confirmed using an indirect immunofluorescence test for the detection of antiplatelet antibodies RESULTS: Overall, we found that antiplatelet antibodies were present in 37.54% (19/51) of patients with chronic hepatitis B before IFN-alpha therapy and in 35.29% (18/51) after therapy. Moreover, antiplatelet antibodies were found in 20% (8/40) of patients with chronic hepatitis C before and after IFN-alpha therapy. CONCLUSIONS: Therapy with IFN-alpha did not induce antiplatelet antibodies in patients with chronic viral hepatitis B or C. Thrombocytopenia observed during IFN-alpha therapy in our study was not due to the development of antiplatelet antibodies.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Antibodies/*chemistry,Autoantibodies/blood,Blood Platelets/*immunology,Cell Adhesion,Female,Fluorescent Antibody Technique, Indirect,Hepatitis B/*immunology/therapy,Hepatitis C/*immunology,Hepatitis, Viral, Human/*immunology,Humans,Immunoglobulin G/*chemistry,Interferon-alpha/*therapeutic use,Male,Middle Aged,Spleen/ultrasonography,Thrombocytopenia/etiology,Treatment Outcome
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/23772
ISSN: 0172-6390
Link: http://www.ncbi.nlm.nih.gov/pubmed/18019713
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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