Antitumour and toxic effects on Wistar rats of two new platinum complexes (Journal article)

Charalabopoulos, K./ Karkabounas, S./ Ioachim, E./ Papalimneou, V./ Syrigos, K./ Evangelou, A./ Agnantis, N./ Hadjiliadis, N.

BACKGROUND: Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS: Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(NH3)2(ala)](NO3), respectively, were synthesized and pure samples were obtained by means of flash chromatography. These complexes were tested on benzo(a)pyrene-induced tumours in Wistar rats to detect their antitumour and toxic effects. RESULTS: There was a statistically significant prolongation of the mean survival time of the animals in the two groups tested (272 +/- 18 days and 246 +/- 26 days, respectively) compared to the control group (195 +/- 22 days) (P < 0.001). Toxic effects included a decrease in leucocyte cell count, mild haemolysis, mild haematuria, mild hepatotoxicity, elevated body temperature and hair loss. All of these effects were reversible after drug discontinuation. CONCLUSIONS: The two new platinum complexes described here appear to have an effective antitumour activity without severe toxicity when tested on Wistar rats.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Antineoplastic Agents/*pharmacology/*toxicity,Benzo(a)pyrene/toxicity,Hematuria/chemically induced,Hemolysis/drug effects,Humans,Leukopenia/chemically induced,Liver/drug effects,Male,Organoplatinum Compounds/*pharmacology/*toxicity,Rats,Rats, Wistar,Sarcoma, Experimental/chemically induced/drug therapy/pathology
ISSN: 0014-2972
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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