Appearance of thymosin alpha 1 in supernatants of monocytes incubated with prothymosin alpha (Journal article)

Frillingos, S./ Seferiadis, K./ Papanastasiou, M./ Baxevanis, C. N./ Frangou-Lazaridis, M./ Economou, M./ Papamichail, M./ Tsolas, O.

Prothymosin alpha, a polypeptide of 109 to 111 amino acid residues, contains the entire thymosin alpha 1 sequence (residues 1-28) at its amino terminal. Human peripheral blood monocytes incubated with prothymosin alpha release thymosin alpha 1 in the culture supernatants. In addition total RNA is found to increase. The production of thymosin alpha 1 involves de novo protein synthesis as shown by the kinetics of this release and its inhibition by actinomycin D and cycloheximide. Thymosin alpha 1 release, possibly in association with HLA-DR, stimulates the proliferation of the T cell population.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Cells, Cultured,Humans,Kinetics,Lymphocyte Culture Test, Mixed,Monocytes/*metabolism,Protein Precursors/genetics/isolation & purification/*metabolism,RNA, Messenger/genetics/metabolism,Swine,T-Lymphocytes/metabolism,Thymosin/*analogs & derivatives/genetics/isolation & purification/metabolism,Thymus Gland/metabolism,Time Factors
ISSN: 0003-9861
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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