Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis (Journal article)

Liu, T./ Korantzopoulos, P./ Xu, G./ Shehata, M./ Li, D./ Wang, X./ Li, G.

AIMS: Recent observations have raised concerns regarding the activation of the renin-angiotensin system and the development of atrial fibrillation (AF). Some initial studies indicated an association between an angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and AF, however, the results have been inconsistent. Our aim was to perform a meta-analysis of relevant studies to assess the validity of this association. METHODS AND RESULTS: PubMed, Cochrane clinical trials database, and EMBASE were searched through July 2009, and a manual search was also performed. Of the 68 initially identified studies, 18 case-control studies with 7577 patients were finally analysed. No statistically significant associations were found between the ACE I/D polymorphism and AF risk in the genetic additive model and dominant model, whereas a significant association was observed in the recessive model. A significant heterogeneity between individual studies was evident in all three models. Subgroup analyses showed a strong association between the ACE I/D polymorphism and hypertensive AF without significant heterogeneity. CONCLUSION: Our meta-analysis suggests that there is insufficient evidence to demonstrate an association between ACE I/D polymorphism and AF risk. However, there seems to be a significant association between ACE I/D gene polymorphic variation and AF in patients with hypertension. Additional studies are warranted to further explore this association in ethnically diverse populations and varied cardiovascular substrates.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Atrial Fibrillation/epidemiology/*genetics/physiopathology,Case-Control Studies,Female,Humans,INDEL Mutation/*genetics,Male,Middle Aged,Peptidyl-Dipeptidase A/*genetics,Polymorphism, Genetic/genetics,Renin-Angiotensin System/physiology,Risk Factors
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/23675
ISSN: 1532-2092
Link: http://www.ncbi.nlm.nih.gov/pubmed/21076147
http://europace.oxfordjournals.org/content/13/3/346.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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