Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome (Journal article)

Lazaros, L./ Markoula, S./ Xita, N./ Giannopoulos, S./ Gogou, P./ Lagos, G./ Kyritsis, A. P./ Georgiou, I.


OBJECTIVE: The vascular protective effects of estrogens are mediated by their binding to the two known estrogen receptors. In this study, we examine the association of stroke with two common polymorphisms of the ESR1 gene in patients with metabolic syndrome. MATERIALS AND METHODS: DNA from 130 patients hospitalized for ischemic stroke and 240 healthy controls were genotyped for ESR1 PvuII and XbaI polymorphisms. Results - Comparing female and male patients, it was found that CCGG diplotype is more frequent in male patients (P = 0.03). In addition, the AA genotype is associated with the onset of stroke at a younger age in the male patient group (P < 0.05). CONCLUSIONS: These findings suggest that PvuII and XbaI polymorphisms may affect the age at onset of the first stroke and the probability of developing cerebrovascular disease.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Age of Onset,Aged,Blood Glucose/metabolism,Brain/pathology/radiography,Dyslipidemias/diagnosis/epidemiology,Electrocardiography,Estrogen Receptor alpha/*genetics,Female,Gene Expression/*genetics,Gene Frequency,Genotype,Humans,Hypertension/diagnosis/epidemiology,Magnetic Resonance Imaging,Male,Metabolic Syndrome X/diagnosis/*epidemiology/metabolism,Middle Aged,Obesity/diagnosis/epidemiology,*Polymorphism, Genetic,Stroke/diagnosis/*epidemiology/*genetics,Tomography, X-Ray Computed
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23659
ISSN: 1600-0404
Link: http://www.ncbi.nlm.nih.gov/pubmed/17854418
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0404.2007.00926.x/asset/j.1600-0404.2007.00926.x.pdf?v=1&t=h0b2c2q5&s=1e2db5e949f09ceb113184541820f693c85cc1b2
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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