Association of serum IgM kappa monoclonicity in patients with Sjogren's syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary glands (Journal article)

Moutsopoulos, H. M./ Tzioufas, A. G./ Bai, M. K./ Papadopoulos, N. M./ Papadimitriou, C. S.


Minor salivary gland biopsy specimens from 11 patients with primary Sjogren's syndrome with circulating monoclonal IgM kappa cryoglobulins, seven without cryoglobulins, and four patients with rheumatoid arthritis and Sjogren's syndrome (one with monoclonal and three with polyclonal cryoglobulins) were examined by the peroxidase antiperoxidase bridge technique, using antihuman kappa and lambda antibodies. In 6/11 patients with primary Sjogren's syndrome and in one patient with Sjogren's syndrome and rheumatoid arthritis with monoclonal cryoglobulins a predominance of plasma cells containing intracytoplasmic kappa light chains was found (kappa:lambda greater than 3:1). Two of those seven patients had immunohistological features of immunocytomas. In the other five patients with circulating monoclonal cryoglobulins the kappa:lambda ratio of positive cells did not exceed 3:1, while six out of seven patients without cryoglobulins and the patients with rheumatoid arthritis and Sjogren's syndrome with polyclonal cryoglobulins had almost equal numbers of kappa and lambda stained cells. One of seven patients with primary Sjogren's syndrome without cryoglobulins had an increased number of lambda light chain positive cells, indicating a non-secretory lambda monoclonal population. These findings suggest that the main area of B cell monoclonal expansion in primary Sjogren's syndrome may be the affected exocrine glands.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Arthritis, Rheumatoid/complications,Cryoglobulins/immunology,Female,Humans,Immunoenzyme Techniques,Immunoglobulin M/*immunology,Immunoglobulin kappa-Chains/*analysis,Immunoglobulin lambda-Chains/analysis,Middle Aged,Plasma Cells/*immunology,Salivary Glands, Minor/*immunology,Sjogren's Syndrome/complications/*immunology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23641
ISSN: 0003-4967
Link: http://www.ncbi.nlm.nih.gov/pubmed/2124096
http://ard.bmj.com/content/49/11/929.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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