Associations of ESR2 AluI (G/A) polymorphism with ischemic stroke in Caucasians (Journal article)

Markoula, S./ Milionis, H./ Lazaros, L./ Spengos, K./ Vassilopoulou, S./ Chatzistefanidis, D./ Kargiotis, O./ Georgiou, I./ Kyritsis, A. P.


Raising interest towards genes implicates the effect of estrogen receptor-alpha (ESR1) gene on cerebrovascular disease, but data are lacking regarding the effect of estrogen receptor-beta (ESR2) gene. We assessed the hypothesis that AluI (G/A) polymorphism of the ESR2 gene (rs 4986938) is associated with ischemic stroke in a Caucasian population. Four hundred twenty four consecutive stroke patients and 430 age and gender-matched controls were enrolled in three stroke centers in Greece over one-year period. Patients and controls were compared in regard to the prevalence of the aforementioned polymorphism. No association was found between variations in the ESR2 gene and risk of stroke or stroke subtype in men and women. Of note, a gender-specific association of G allele with the onset of stroke at a younger age in male patients was found (63.68+/-12.687years in G allele (GG+AG) carriers vs. 68.95+/-10.757years in non-carriers (AA), p=0.008). Further population independent studies are needed to establish the role of ESR2 gene polymorphisms in relation to ischemic stroke in both genders. Such studies could lead to ERbeta agonists being validated in individuals with certain genotypes and/or alleles towards the development of efficient strategies to preventing ischemic stroke in both men and women.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23627
ISSN: 1878-5883
Link: http://www.ncbi.nlm.nih.gov/pubmed/22305517
http://ac.els-cdn.com/S0022510X12000081/1-s2.0-S0022510X12000081-main.pdf?_tid=b98396a99bd35e6003306376cb07e62d&acdnat=1332859774_0821253751d251cf41b0de68fa33fc1a
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Markoula-2012-Associations of ESR2.pdf170.05 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/23627
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.