Atrial electrical remodeling in a canine model of sinus node dysfunction (Journal article)

Li, G./ Liu, E./ Liu, T./ Wang, J./ Dai, J./ Xu, G./ Korantzopoulos, P./ Yang, W.

AIMS: To study atrial tachycardia-induced electrical remodeling in a canine model of sinus node dysfunction (SND). MATERIALS AND METHODS: A canine model of SND was established by contacting a cotton patch with 20% formaldehyde on the sinus node. Atrial effective refractory period (ERP), ERP dispersion, and inducibility of atrial fibrillation (AF) were recorded at multiple sites in the atrium, before and after SND induction as well as after rapid atrial pacing. The recovery of atrial ERP in the left and right atrium (LA and RA) after cessation of atrial pacing was also recorded. RESULTS: Compared with baseline, the atrial ERPs were shortened after SND (P<0.05). After rapid atrial stimulation, the atrial ERPs were further decreased significantly (P<0.05), and the dispersion of atrial ERPs measured at different pacing cycle lengths (PCLs) showed significant variation. Seven sites were used to induce AF in each dog (56 sites in 8 dogs). The average duration and inducibility of AF after SND was increased compared with baseline (16.5+/-4.7 vs 2.3+/-1.2 s and 12/56 vs 4/56 sites, P<0.05). After rapid atrial stimulation, the average duration and inducibility of AF were further increased (16.5+/-4.7 vs 33.6+/-16.1 s and 12/56 vs 25/56 sites, P<0.05). The recovery of atrial ERP in LA was significantly delayed compared to the RA. CONCLUSION: SND induces atrial electrical remodeling which is further aggravated by atrial tachycardia. Therefore, SND creates an electrophysiological substrate that facilitates AF initiation and perpetuation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Atrial Fibrillation/complications/*physiopathology,*Disease Models, Animal,Dogs,*Electrocardiography/methods,Sick Sinus Syndrome/complications/*physiopathology,Tachycardia, Ectopic Atrial/complications/physiopathology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/23615
ISSN: 1874-1754
Link: http://www.ncbi.nlm.nih.gov/pubmed/19545921
http://ac.els-cdn.com/S0167527309006482/1-s2.0-S0167527309006482-main.pdf?_tid=afc3a50268f4d95c49cc28d6b0d81b9f&acdnat=1333964373_8109df783defb9ac32930a28843a7879
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Li-2011-Atrial electrical re.pdf427 kBAdobe PDFView/Open    Request a copy


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/23615
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.