Avoiding and managing bleeding complications in patients with non-ST-segment elevation acute coronary syndromes (Journal article)

Potsis, T. Z./ Katsouras, C./ Goudevenos, J. A.

Antithrombotic therapy coupled with early use of cardiac catheterization and revascularization have decreased morbidity and mortality rates in patients who have acute ischemic heart disease but who carry a risk for bleeding. Bleeding complications in patients with acute coronary syndromes are associated with worse clinical outcomes, including recurrent ischemic events and death. Determining the appropriate balance between preventing ischemic events and causing bleeding in patients with acute coronary syndromes present a challenging problem for clinicians. Antithrombotics studied in recent clinical trials that have focused on bleeding reduction include bivalirudin and fondaparinux. In this review, the incidence, predictors, and clinical outcomes associated with bleeding are discussed. Furthermore, the association between antithrombotic agents and bleeding and propose strategies to prevent bleeding complications are also discussed.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acute Coronary Syndrome/physiopathology/*therapy,Anticoagulants/*therapeutic use,*Electrocardiography,Factor X/antagonists & inhibitors,Fibrinolytic Agents/adverse effects/*therapeutic use,Heart Catheterization/adverse effects/*methods,Hemorrhage/drug therapy/etiology/*prevention & control,Humans,Myocardial Revascularization/adverse effects/*methods,Polysaccharides/therapeutic use,Prognosis,Risk Factors
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23567
ISSN: 1940-1574
Link: http://www.ncbi.nlm.nih.gov/pubmed/18508853
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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