Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C (Journal article)

Economou, M./ Milionis, H./ Filis, S./ Baltayiannis, G./ Christou, L./ Elisaf, M. S./ Tsianos, E.


BACKGROUND: Hepatitis C virus (HCV) partially interacts with low-density lipoprotein (LDL) receptors, suggesting a role for lipids in regulating HCV clearance. Our aim was to study if baseline lipids can discriminate responders from non-responders among patients with HCV infection. METHODS: A total of 109 HCV patients were studied. Laboratory measurements included serum lipids, aminotransferases and viral load, as well as HCV genotype determinations. RESULTS: Responders (n = 53) had significantly higher serum baseline levels of total cholesterol, LDL cholesterol and apolipoprotein B compared to non-responders (n = 56). Multivariate logistic regression analysis showed that a 10 mg/dL increase in total cholesterol was associated with 3.02 higher odds of responding to treatment (95% CI 1.74-5.32, P < 0.001), while a 10 mg/dL increase in apolipoprotein B levels was associated with 1.81 higher odds of responding to treatment (95% CI 1.37-2.54, P < 0.001), after adjustment for age, sex, body mass index (BMI), smoking habits, baseline viral load, liver histology and administration of pegylated interferon. An inverse association between BMI and response to treatment was also evident (adjusted odds ratio 0.73, 95% CI 0.55-0.96; P = 0.03). CONCLUSION: Baseline serum total cholesterol levels and BMI could be helpful in discriminating responders to antiviral therapy among patients with HCV infection.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antiviral Agents/*therapeutic use,Apolipoproteins B/*blood,Cholesterol/*blood,Cholesterol, LDL/*blood,Female,Hepatitis C, Chronic/*blood/*drug therapy,Humans,Male,Middle Aged,Predictive Value of Tests,Retrospective Studies
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23544
ISSN: 1440-1746
Link: http://www.ncbi.nlm.nih.gov/pubmed/17498221
http://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2007.04911.x/asset/j.1440-1746.2007.04911.x.pdf?v=1&t=h0p11ldo&s=1763ab797979252a5963b724c5973b85ef31f9b6
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Economou-2008-Baseline cholesterol.pdf88.44 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/23544
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.