Bcl2-interacting killer CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications (Journal article)

Hatzimichael, E./ Dasoula, A./ Kounnis, V./ Benetatos, L./ Nigro, C. L./ Lattanzio, L./ Papoudou-Bai, A./ Dranitsaris, G./ Briasoulis, E./ Crook, T.


Abstract BIK (bcl2-interacting killer) is the founding member of the BH3-only bcl-2 family of pro-apoptotic proteins, which is suppressed in various cancers. In multiple myeloma (MM), BIK has been shown to be epigenetically silenced in vitro, but there is a lack of clinical data. We investigated the CpG methylation status of the BIK promoter in a well-characterized clinical series of patients with MM and investigated its clinical relevance. Forty patients with MM (21 male, 19 female; mean age 66) were studied. According to the International Staging System (ISS) they were classified as 16 patients with stage I, 12 patients with stage II and 12 patients with stage III disease. Methylation in the BIK CpG island was assessed by methylation-specific polymerase chain reaction (MSP) assay. Logistic regression analysis was used to investigate associations between gene methylation and age, ISS stage, performance status, extramedullary disease, bone disease, anemia (hemoglobin
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23530
ISSN: 1029-2403
Link: http://www.ncbi.nlm.nih.gov/pubmed/22288719
http://informahealthcare.com/doi/abs/10.3109/10428194.2012.661854
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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