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https://olympias.lib.uoi.gr/jspui/handle/123456789/23518Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsouchnikas, I. | en |
| dc.contributor.author | Dounousi, E. | en |
| dc.contributor.author | Papakonstantinou, S. | en |
| dc.contributor.author | Ioannou, K. | en |
| dc.contributor.author | Kelesidis, A. | en |
| dc.contributor.author | Kotzadamis, N. | en |
| dc.contributor.author | Xanthopoulou, K. | en |
| dc.contributor.author | Tsakiris, D. | en |
| dc.date.accessioned | 2015-11-24T19:33:16Z | - |
| dc.date.available | 2015-11-24T19:33:16Z | - |
| dc.identifier.issn | 1440-1797 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23518 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | C-Reactive Protein/analysis | en |
| dc.subject | Cholesterol, LDL/blood | en |
| dc.subject | Erythropoietin/*therapeutic use | en |
| dc.subject | Female | en |
| dc.subject | Heptanoic Acids/*therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Pyrroles/*therapeutic use | en |
| dc.subject | *Renal Dialysis | en |
| dc.title | Beneficial effect of atorvastatin on erythropoietin responsiveness in maintenance haemodialysis patients | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1111/j.1440-1797.2009.01084.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19422526 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1440-1797.2009.01084.x/asset/j.1440-1797.2009.01084.x.pdf?v=1&t=h0ul4dos&s=c9a7a07acc74ae13c899051be2973569697b79ef | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | AIM: To evaluate the effect of atorvastatin on erythropoietin responsiveness and whether this effect is mediated by C-reactive protein (CRP) reduction in prevalent dyslipidemic, haemodialysis patients. METHODS: We studied prospectively 33 stable, iron-repleted haemodialysis patients with low-density lipoprotein cholesterol (LDL) > or =2.58 mmol/L, who received 20 mg atorvastatin aiming to achieve the target of LDL <2.58 mmol/L, over a period of 9 months. Twenty-five patients completed the study, 15 men, with mean age 66.1 +/- 8.2 years. The duration of haemodialysis was 56.6 +/- 63.1 months and 5/25 patients were diabetics. Total serum cholesterol, triglycerides, high-density lipoprotein cholesterol, LDL, haemoglobin, albumin, intact parathyroid hormone, serum iron, ferritin, total iron binding capacity, CRP and weekly dose of erythropoietin/body weight/haemoglobin were analysed. RESULTS: Twenty of the 25 patients (80%) achieved the goal of LDL <2.58 mmol/L. There was a significant decrease in total cholesterol (5.77 +/- 0.88 to 4.16 +/- 0.96 mmol/L, P < 0.001) and LDL (3.59 +/- 0.77 to 1.94 +/- 0.77 mmol/L, P < 0.001). Haemoglobin increased from 121 +/- 11 to 126 +/- 7 g/L (P < 0.05), while weekly dose of erythropoietin/body weight/haemoglobin decreased significantly from 8.34 +/- 3.70 to 7.87 +/- 3.11 IU/kg per haemoglobin (P < 0.05). CRP decreased not significantly from 7.0 +/- 6.1 to 4.5 +/- 2.2 mg/L. CONCLUSION: Dyslipidemia of haemodialysis patients was treated safely and effectively with atorvastatin, but a fifth of the patients failed to achieve the therapeutic target. Statin therapy resulted in a significant increase of haemoglobin levels and improvement of erythropoietin responsiveness without a significant reduction in CRP levels, suggesting that the beneficial effect of statins on erythropoietin responsiveness may be driven by a mechanism other than CRP reduction. | en |
| heal.journalName | Nephrology (Carlton) | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tsouchnikas-2009-Beneficial effect of.pdf | 110.85 kB | Adobe PDF | View/Open Request a copy |
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