Beneficial effect of rituximab in combination with oral cyclophosphamide in primary chronic cold agglutinin disease (Journal article)

Vassou, A./ Alymara, V./ Chaidos, A./ Bourantas, K. L.


Cold agglutinin disease (CAD) is an uncommon autoimmune hemolytic anemia characterized by B-cell proliferation. Conventional therapies for primary CAD such as corticosteroids, oral alkylating agents, splenectomy, interferon alpha, and plasma exchange are often ineffective at controlling the disease. The anti-CD20 monoclonal antibody rituximab (MabThera) depletes B-lymphocytes and thereby interferes with the production of cold agglutinin. We describe an elderly patient with primary (idiopathic) chronic CAD refractory to steroids who was successfully treated with 4 weekly infusions (375 mg/m2) of rituximab and 6 months of oral cyclophosphamide at a dosage of 60 mg/m2 per day. The increase in hemoglobin level and the decline in the plasma cold agglutinin titer were rapid (from the second rituximab infusion). The hematologic remission persisted for at least 8 months after treatment start, with no adverse effects. Rituximab and cyclophosphamide may be supplementary therapeutic modalities whose combination warrants further clinical investigation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Aged, 80 and over,Anemia, Hemolytic, Autoimmune/diagnosis/*drug therapy,Antibodies, Monoclonal/*administration & dosage,Antibodies, Monoclonal, Murine-Derived,Chronic Disease,Cyclophosphamide/*administration & dosage,Drug Therapy, Combination,Female,Humans,Remission Induction,Salvage Therapy
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23516
ISSN: 0925-5710
Link: http://www.ncbi.nlm.nih.gov/pubmed/16158824
http://www.springerlink.com/content/ml7fjrcrawu8bym8/fulltext.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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