Bone minerals in beta-thalassemia minor (Journal article)

Kalef-Ezra, J./ Challa, A./ Chaliasos, N./ Hatzikonstantinou, I./ Papaefstathiou, I./ Cholevas, V./ Glaros, D./ Lapatsanis, P.

Homozygous beta-thalassemia is a severe hereditary disorder associated with osteopenia. Recently it was suggested that thalassemia minor may be a risk factor for osteoporosis. The purpose of the present study was to investigate this suggestion. Bone mineral status was assessed in 22 premenopausal women and 21 men with beta-thalassemia minor. In vivo neutron activation analysis was applied to measure hand-bone phosphorus (HBP), single-photon absorptiometry to measure forearm bone mineral content (BMC), and dual-energy X-ray absorptiometry to measure spinal bone mineral density (BMD). Comparison of the HBP, BMC, and BMD values with those of sex- and age-matched healthy subjects without the beta-thalassemia trait failed to indicate a statistically significant difference for either sex group. Concerning the biochemical markers of bone metabolism that were studied (serum calcium, phosphate, alkaline phosphatase, osteocalcin, and parathyroid hormone, and 3-h fasting urine calcium-to-urine creatinine ratio) no difference was observed between the study subjects and matched controls. In conclusion, the present study showed that subjects with beta-thalassemia minor are not at risk for osteoporosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Absorptiometry, Photon,Adult,Aging/metabolism,Biological Markers/blood/urine,Bone Density/*physiology,Bone Diseases, Metabolic/*physiopathology,Female,Forearm,Hand,Humans,Male,Middle Aged,Neutron Activation Analysis,Phosphorus/metabolism,Premenopause,Sex Factors,beta-Thalassemia/genetics/*physiopathology
ISSN: 8756-3282
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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