The role of E-cadherin/catenin complex in laryngeal cancer (Journal article)

Mittari, E./ Charalabopoulos, A./ Batistatou, A./ Charalabopoulos, K.

In this review the role of the epithelial E-cadherin/catenin complex in cases of laryngeal cancer is discussed. Cancer of the larynx remains the second most common head and neck malignancy. The E-cadherin/catenin complex expression is abnormal in laryngeal squamous cell carcinomas. Loss or reduction of E-cadherin expression is especially observed in supraglottic larynx cancer in relation with poor histological differentiation and/or lymph nodes metastases. Controversial results in some studies regarding the role of the E-cadherin/catenin complex in various anatomical parts of the larynx have been reported. Further studies are needed to establish the importance of the E-cadherin/catenin complex as a potential biomarker in laryngeal cancer diagnosis and prognosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Cadherins/*metabolism,Catenins/*metabolism,Humans,Laryngeal Neoplasms/*metabolism/pathology,Neoplasms, Squamous Cell/*metabolism/pathology,Tumor Markers, Biological/analysis
ISSN: 1812-9269
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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