Chronic skeletal muscle ischemia in rats decreases the inducibility of ventricular tachyarrhythmias after myocardial infarction (Journal article)

Maniotis, C./ Tsalikakis, D. G./ Tzallas, A. T./ Varnavas, V./ Kontaras, K./ Glava, C./ Baltogiannis, G. G./ Papalois, A./ Kolettis, T. M./ Kyriakides, Z. S.


BACKGROUND: Chronic hind-limb ischemia confers cytoprotection after coronary occlusion, but it is unclear whether it ameliorates substrate formation for ventricular tachyarrhythmias (VTs). MATERIALS AND METHODS: Chronic hind-limb ischemia was generated by femoral artery excision in 50 rats, while 25 animals were sham-operated. Left coronary artery ligation was performed after 3 weeks and infarct size was measured 24 hours thereafter. The inducibility of VTs was assessed by programmed electrical stimulation (PES) 4 weeks post-ligation. A score was assigned, based on protocol stage and tachyarrhythmia duration. Monophasic action potentials (MAP) were recorded prior to and 4 weeks after ligation. RESULTS: The infarct size was smaller (p=0.000079) in the ischemic rats (25.7+/-2.1%) than in the controls (41.7+/-2.2%), accompanied by a lower (p=0.029) arrhythmia score (1.05+/-0.38 versus 2.70+/-0.68, respectively). The action potential duration (APD) was shorter (p<0.05) in the ischemic rats prior to ligation and remained stable after 4 weeks. CONCLUSION: Chronic hind limb ischemia limits infarct size and decreases inducible ventricular tachyarrhythmias.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Action Potentials,Animals,Electrocardiography,Heart Rate,Hindlimb/*blood supply,*Ischemic Preconditioning,Muscle, Skeletal/*blood supply,Myocardial Infarction/*complications/pathology,Myocardial Reperfusion Injury/*complications,Myocardium/pathology,Rats,Rats, Wistar,Tachycardia, Ventricular/etiology/*prevention & control
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23121
ISSN: 1791-7549
Link: http://www.ncbi.nlm.nih.gov/pubmed/21753134
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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