Circulating antibodies to prothymosin alpha in systemic lupus erythematosus (Journal article)

Vlachoyiannopoulos, P. G./ Frillingos, S./ Tzioufas, A. G./ Seferiadis, K./ Moutsopoulos, H. M./ Tsolas, O.

Autoantibodies to prothymosin alpha, an immunoactive protein that exists in a large variety of mammalian tissues, were found to be present in patients with systemic lupus erythematosus (SLE) by a new, sensitive, and specific anti-prothymosin alpha ELISA. The antigen was prothymosin alpha, purified by high-pressure liquid chromatography from goat spleen extracts. Sera from 44 SLE patients and 276 healthy individuals were screened for the presence of anti-prothymosin alpha activity; 18% of SLE sera were found to be positive, compared with 1.8% of control sera. This anti-prothymosin alpha activity appears to be idiotypically distinct from either anti-thymosin alpha 1 activity or anti-dsDNA activity, as demonstrated by inhibition experiments. Significant positive correlation exists between anti-prothymosin alpha and anti-dsDNA activities of SLE sera (r = +0.596, n = 36, P less than 0.001), while no correlation was observed with the clinical activity (X2 = 1.239, 0.1 less than P less than 0.5) or with complement levels C3 and C4.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antibodies, Antinuclear/immunology,Autoantibodies/*immunology,Autoantigens/*immunology,Enzyme-Linked Immunosorbent Assay,Humans,Immunoglobulin Idiotypes/analysis,Lupus Erythematosus, Systemic/*immunology,Protein Precursors/*immunology,Thymosin/immunology
ISSN: 0090-1229
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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