Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia (Journal article)

Sipsas, N. V./ Kokori, S. I./ Ioannidis, J. P./ Kyriaki, D./ Tzioufas, A. G./ Kordossis, T.


In a cohort of 204 unselected consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients, the association of circulating autoantibodies to endogenous erythropoietin (EPO) with HIV-1-related anemia was studied. Circulating autoantibodies to EPO were present in 48 (23.5%) of the 204 patients studied. Circulating autoantibodies were an independent predictor of anemia (odds ratio [OR]=5.0; 95% confidence interval [CI], 2.5-9.9), as strong as other known causes of anemia. The association of anti-EPO antibodies with anemia became stronger when the analysis was limited to the group of patients without any medical condition causing anemia (OR=10.4; 95% CI, 3.2-33.9). Moreover, the effect on hemoglobin levels remained significant even after adjusting for other anemia parameters. Anti-EPO autoantibodies were associated with higher EPO levels (r=.25, P=.012) and with a more prominent EPO response to anemia. Our findings suggest that autoimmunity, among other factors, may contribute to the pathogenesis of HIV-1-related anemia.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Aged, 80 and over,Anemia/*etiology,Autoantibodies/*blood,Cohort Studies,Erythropoietin/analysis/*immunology,Female,HIV Infections/*complications/immunology,*Hiv-1,Hemoglobins/analysis,Humans,Male,Middle Aged
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23113
ISSN: 0022-1899
Link: http://www.ncbi.nlm.nih.gov/pubmed/10558967
http://jid.oxfordjournals.org/content/180/6/2044.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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