Clinical significance of creatine kinase isoenzymes for fetal asphyxia in women at labor (Journal article)

Andronikou, S./ Bairaktari, E./ Vasiliadou, A. D./ Stefos, T./ Lolis, D./ Tsolas, O./ Lapatsanis, P. D.


Creatine kinase-brain isoenzyme activity (CK-BB) was measured longitudinally in the serum of 31 pregnant women in the first stage of labor (early and advanced), at delivery, and 1, 6 and 24 h after delivery, in the umbilical cord and in the serum of their neonates on the first day of life. There was no increase in serum CK-BB values of mothers that delivered normally (n = 15) or had an elective cesarean section (n = 5). Pregnant women with signs of fetal distress had an increase in CK-BB levels in the first stage of labor (mean +/- SD 4.5 +/- 4.9 U/l, p < 0.03) and 6 h after delivery (12 +/- 4 U/l, p < 0.0001). Neonates with intrauterine stress also had an increase in their CK-BB to 144 +/- 116 U/l at 6 h of life, in comparison with babies born without signs of stress. It appears that CK-BB during labor and in the first hours of life may be indicative of intrauterine stress.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Asphyxia Neonatorum/*enzymology,Cesarean Section,Creatine Kinase/*blood,Female,Fetal Distress/enzymology,Gestational Age,Humans,Infant, Newborn,Isoenzymes,Labor, Obstetric/blood,Pregnancy,Retrospective Studies,Time Factors
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23061
ISSN: 1015-3837
Link: http://www.ncbi.nlm.nih.gov/pubmed/7710673
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000264182
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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