Coexpression of neuronal, glial, and major histocompatibility complex class II antigens on retinoblastoma cells (Journal article)

Detrick, B./ Chader, G. J./ Rodrigues, M./ Kyritsis, A. P./ Chan, C. C./ Hooks, J. J.

This study identifies the presence of major histocompatibility complex class II antigens on retinoblastoma cells. In addition, the modulation of HLA-DR by interferon-gamma as well as the preferential expression of this major histocompatibility complex molecule over HLA-DQ is described. Double labeling experiments revealed that HLA-DR antigen is shared concomitantly with cells of glial and neuronal character. Investigations such as these underscore the possibility that expression of major histocompatibility complex class II antigens may function as immunological components in the host or play a role in the cellular differentiation of these tumor cells.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antigens/analysis,Arrestin,Child, Preschool,Eye Neoplasms/*immunology,Eye Proteins/analysis,Fluorescent Antibody Technique,Glial Fibrillary Acidic Protein/analysis,HLA-D Antigens/*analysis,HLA-DQ Antigens/*analysis,HLA-DR Antigens/*analysis,Humans,Interferon-gamma/pharmacology,Male,Neuroglia/*immunology,Neurons/*immunology,Retina/immunology,Retinoblastoma/*immunology,Tumor Cells, Cultured
ISSN: 0008-5472
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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