Combination therapy with recombinant human erythropoietin, interferon-alpha-2b and granulocyte-macrophage colony-stimulating factor in idiopathic myelofibrosis (Journal article)

Bourantas, K. L./ Tsiara, S./ Christou, L./ Repousis, P./ Konstantinidou, P./ Bai, M./ Seferiadis, K.

Seven patients, 3 men and 4 women 48-72 years of age and suffering from idiopathic myelofibrosis were given a combination of recombinant human erythropoietin (r-hu-Epo), interferon-alpha-2b (IFN) and GM-CSF, in an attempt to treat their pancytopenia and marrow fibrosis. The dose of r-hu-Epo was 200 U/kg 3 times weekly, that of IFN was 3 x 10(6)/U 3 times weekly, and that of GM-CSF was 250 micrograms/m2/daily. The duration of therapy ranged from 3 to 6 months for r-hu-Epo and IFN and was 3 weeks for GM-CSF. The treatment regimen had a beneficial effect on all patients. The levels of hemoglobin increased in all patients but particularly in 5 (2 of whom had been dependent on red blood cell transfusions). Splenomegaly decreased significantly in 4 patients. Fibrosis in the bone marrow decreased in 2 patients. Three patients also had an increase in the number of white blood cells during the therapy with GM-CSF. We observed mild side effects in 6 of our patients. One patient had severe side effects from IFN and treatment was discontinued. In conclusion, the combination of r-hu-Epo, IFN and GM-CSF may improve the anemia (due to r-hu-Epo), increase the white blood cell count (due to GM-CSF) and reduce the marrow fibrosis (probably due to IFN) in patients with idiopathic myelofibrosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Bone Marrow/pathology,Erythropoietin/*therapeutic use,Female,Granulocyte-Macrophage Colony-Stimulating Factor/*therapeutic use,Hemoglobins/metabolism,Humans,Interferon-alpha/*therapeutic use,Leukocyte Count,Male,Middle Aged,Platelet Count,Primary Myelofibrosis/blood/pathology/*therapy,Recombinant Proteins/therapeutic use,Spleen/pathology,beta 2-Microglobulin/metabolism
ISSN: 0001-5792
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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