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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sotiriadis, A. | en |
| dc.contributor.author | Vartholomatos, G. | en |
| dc.contributor.author | Pavlou, M. | en |
| dc.contributor.author | Kolaitis, N. | en |
| dc.contributor.author | Dova, L. | en |
| dc.contributor.author | Stefos, T. | en |
| dc.contributor.author | Paraskevaidis, E. | en |
| dc.contributor.author | Kalantaridou, S. N. | en |
| dc.date.accessioned | 2015-11-24T19:29:22Z | - |
| dc.date.available | 2015-11-24T19:29:22Z | - |
| dc.identifier.issn | 1046-7408 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22967 | - |
| dc.rights | Default Licence | - |
| dc.subject | Abortion, Habitual/blood/*genetics | en |
| dc.subject | Adult | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Factor V/genetics | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Methylenetetrahydrofolate Reductase (NADPH2)/genetics | en |
| dc.subject | *Mutation | en |
| dc.subject | Polymerase Chain Reaction | en |
| dc.subject | Pregnancy | en |
| dc.subject | Prothrombin/genetics | en |
| dc.subject | Thrombophilia/blood/*genetics | en |
| dc.title | Combined thrombophilic mutations in women with unexplained recurrent miscarriage | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1111/j.1600-0897.2006.00454.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17217367 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2006.00454.x/asset/j.1600-0897.2006.00454.x.pdf?v=1&t=h0kwwn6t&s=eaf1f25cd7c724fde87d086888690108317647cb | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | PROBLEM: To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group. METHOD OF STUDY: Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage. RESULTS: None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages<or=10 weeks, statistical significance was not reached due to the small size of the >10 weeks' subgroup. There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017). CONCLUSIONS: Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage. | en |
| heal.journalName | Am J Reprod Immunol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Sotiriadis-2007-Combined thrombophil.pdf | 557.85 kB | Adobe PDF | View/Open Request a copy |
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