1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22930
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBassukas, I. D.en
dc.date.accessioned2015-11-24T19:28:50Z-
dc.date.available2015-11-24T19:28:50Z-
dc.identifier.issn0008-5472-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22930-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCarcinoma, Renal Cell/*pathologyen
dc.subject*Cell Division/drug effectsen
dc.subjectHumansen
dc.subjectKidney Neoplasms/*pathologyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subject*Models, Biologicalen
dc.subject*Models, Statisticalen
dc.subjectNeoplasm Transplantationen
dc.subjectOrgan Sizeen
dc.subjectSuramin/pharmacologyen
dc.subjectTime Factorsen
dc.subjectTransplantation, Heterologousen
dc.titleComparative Gompertzian analysis of alterations of tumor growth patternsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8044786-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1994-
heal.abstractWe have shown previously that different patterns of growth (including classical Gompertzian, exponential, and hyperexponential) can be described based on the Gompertzian difference equation, In G(t+s) = a+b In G(t) [G(t), tumor size at time t; s, constant time interval of a stroboscopic set of tumor size measurements], by the initial or intrinsic growth rate, a, and the exponential rate of growth deceleration, b (I. D. Bassukas and B. Maurer-Schultze, Growth Dev. Aging, 52: 113-122, 1988). Particularly, the possible effects of antineoplastic treatments on this latter factor have not been adequately appreciated to date. In the present study a new method of comparison of growth process is introduced, which consists of two steps. (a) The corresponding growth patterns are compared with each other on the basis of the Gompertzian difference equation using an analysis of variance algorithm. The result indicates whether or not there is an alteration of the growth pattern and, if there is one, whether it refers to alterations of the a and/or b values for the growth patterns. (b) The ultimate effect of any perturbation is assessed by using the limit (for t-->infinity) of the quotient of the tumor sizes after and before perturbation to characterize it as stimulation or inhibition. The present approach introduces a new quality of tumor growth perturbations; tumor growth may be altered although being neither inhibited nor stimulated, a phenomenon with biological significance still to be evaluated. The application of this method to the treatment with suramin of a human renal cell carcinoma xenograft in nude mice reveals a complex alteration of its growth pattern. Suramin simultaneously inhibits both the initial or intrinsic growth rate and the exponential rate of growth deceleration of this tumor. Consequently, this tumor starts with a lower growth rate in the presence of suramin; however, this rate also decelerates more slowly as a function of tumor growth, so that treated tumors, although initially inhibited, grow larger than controls.en
heal.journalNameCancer Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Bassukas-1994-comparative gompertzian analysis.pdf1.77 MBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons