Comparison of hemoglobin A1c and fasting glucose criteria to diagnose diabetes among people with metabolic syndrome and fasting glucose above 100 mg/dL (5.5 mmol/L) (Journal article)
Liberopoulos, E. N./ Florentin, M./ Kei, A./ Mountzouri, E./ Agouridis, A./ Elisaf, M. S.
The aim of this study was to compare hemoglobin A(1c) (HbA(1c)) and fasting glucose for the diagnosis of diabetes among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L). Consecutive individuals (N=142) with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L) but without a self-reported history of diabetes who visited the outpatient lipid and obesity clinic of the University Hospital of Ioannina, Greece from January through September 2009 were included. HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L) were used separately to define diabetes. Overall, 29.5% of patients had both HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L), 25.3% had HbA(1c)> or =6.5% but fasting glucose <126 mg/dL (7 mmol/L), and 9.1% had HbA(1c) <6.5% but fasting glucose > or =126 mg/dL (7 mmol/L). A greater proportion of patients reached a diagnosis of diabetes based on the HbA(1c) criterion (n=78, 54.9%) compared with the fasting glucose criterion (n=55, 38.7%, P=.000). A large proportion of patients (44.8%) with impaired fasting glucose (fasting glucose 100-125 mg/dL; 5.6-6.9 mmol/L) would be classified as diabetics using the HbA(1c) criterion. Implication of the HbA(1c) criterion may increase the rate of diabetes diagnosis among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L).
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||Analysis of Variance,Biological Assay,Blood Glucose/*metabolism,Diabetes Mellitus, Type 2/*diagnosis/metabolism/physiopathology,Fasting/*metabolism/physiology,Female,Health Status Indicators,Hemoglobin A, Glycosylated/*analysis,Humans,Hyperglycemia/*diagnosis/metabolism/physiopathology,Insulin Resistance,Male,Metabolic Syndrome X/*physiopathology,Middle Aged,Statistics, Nonparametric|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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