Comparison of hemoglobin A1c and fasting glucose criteria to diagnose diabetes among people with metabolic syndrome and fasting glucose above 100 mg/dL (5.5 mmol/L) (Journal article)

Liberopoulos, E. N./ Florentin, M./ Kei, A./ Mountzouri, E./ Agouridis, A./ Elisaf, M. S.

The aim of this study was to compare hemoglobin A(1c) (HbA(1c)) and fasting glucose for the diagnosis of diabetes among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L). Consecutive individuals (N=142) with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L) but without a self-reported history of diabetes who visited the outpatient lipid and obesity clinic of the University Hospital of Ioannina, Greece from January through September 2009 were included. HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L) were used separately to define diabetes. Overall, 29.5% of patients had both HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L), 25.3% had HbA(1c)> or =6.5% but fasting glucose <126 mg/dL (7 mmol/L), and 9.1% had HbA(1c) <6.5% but fasting glucose > or =126 mg/dL (7 mmol/L). A greater proportion of patients reached a diagnosis of diabetes based on the HbA(1c) criterion (n=78, 54.9%) compared with the fasting glucose criterion (n=55, 38.7%, P=.000). A large proportion of patients (44.8%) with impaired fasting glucose (fasting glucose 100-125 mg/dL; 5.6-6.9 mmol/L) would be classified as diabetics using the HbA(1c) criterion. Implication of the HbA(1c) criterion may increase the rate of diabetes diagnosis among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L).
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Analysis of Variance,Biological Assay,Blood Glucose/*metabolism,Diabetes Mellitus, Type 2/*diagnosis/metabolism/physiopathology,Fasting/*metabolism/physiology,Female,Health Status Indicators,Hemoglobin A, Glycosylated/*analysis,Humans,Hyperglycemia/*diagnosis/metabolism/physiopathology,Insulin Resistance,Male,Metabolic Syndrome X/*physiopathology,Middle Aged,Statistics, Nonparametric
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/22910
ISSN: 1751-7176
Link: http://www.ncbi.nlm.nih.gov/pubmed/20629819
http://onlinelibrary.wiley.com/store/10.1111/j.1751-7176.2010.00318.x/asset/j.1751-7176.2010.00318.x.pdf?v=1&t=h0m77p2q&s=9567df8dccac1e7d515a92127d3fe2ff331fa5d9
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