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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Glantzounis, G. K. | en |
| dc.contributor.author | Yang, W. | en |
| dc.contributor.author | Koti, R. S. | en |
| dc.contributor.author | Mikhailidis, D. P. | en |
| dc.contributor.author | Seifalian, A. M. | en |
| dc.contributor.author | Davidson, B. R. | en |
| dc.date.accessioned | 2015-11-24T19:27:29Z | - |
| dc.date.available | 2015-11-24T19:27:29Z | - |
| dc.identifier.issn | 0007-1323 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22816 | - |
| dc.rights | Default Licence | - |
| dc.subject | Acetylcysteine/*administration & dosage | en |
| dc.subject | Animals | en |
| dc.subject | Free Radical Scavengers/*administration & dosage | en |
| dc.subject | Indocyanine Green/pharmacokinetics | en |
| dc.subject | Ischemic Preconditioning/methods | en |
| dc.subject | Liver/*blood supply | en |
| dc.subject | Liver Circulation | en |
| dc.subject | Liver Function Tests | en |
| dc.subject | Microcirculation | en |
| dc.subject | Rabbits | en |
| dc.subject | Reperfusion Injury/*prevention & control | en |
| dc.title | Continuous infusion of N-acetylcysteine reduces liver warm ischaemia-reperfusion injury | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1002/bjs.4694 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15376207 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/bjs.4694/asset/4694_ftp.pdf?v=1&t=h0nql5sr&s=7b5a227c8c0fafb89ab6cb84103958347318b4b6 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | BACKGROUND: N-acetylcysteine (NAC) may modulate the initial phase (less than 2 h) of liver warm ischaemia-reperfusion (IR) injury but its effect on the late phase remains unclear. The present study investigated the role of NAC during the early and late phases in a rabbit lobar IR model. METHODS: Liver ischaemia was induced by inflow occlusion to the median and left liver lobes for 60 min, followed by 7 h of reperfusion. In the NAC group (n = 6), NAC was administered intravenously at 150 mg per kg over the 15 min before reperfusion and maintained at 10 mg per kg per h during reperfusion. In the IR group (n = 6), 20 ml 5 per cent dextrose was infused over the 15 min before reperfusion and continued at a rate of 10 ml/h. Animals in a sham operation group (n = 6) underwent laparotomy but no liver ischaemia. All animals were killed at the end of the experiment. RESULTS: Intracellular tissue oxygenation was improved after the second hour of reperfusion in animals treated with NAC compared with that in the IR group (P = 0.023). Hepatic microcirculation improved after 5 h of reperfusion (P = 0.036) and liver injury was reduced after 5 h, as indicated by alanine aminotransferase activity (P = 0.007) and indocyanine green clearance (uptake, P = 0.001; excretion, P = 0.032). CONCLUSION: The main protective effect of NAC becomes apparent 5 h after hepatic ischaemic injury. | en |
| heal.journalName | Br J Surg | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Glantzounis-2004-Continuous infusion.pdf | 157.35 kB | Adobe PDF | View/Open Request a copy |
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