Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake (Journal article)

Alexiou, G. A./ Tsiouris, S./ Vartholomatos, G./ Fotakopoulos, G./ Papadopoulos, A./ Kyritsis, A. P./ Voulgaris, S./ Fotopoulos, A. D.


OBJECTIVES: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. MATERIAL AND METHODS: In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision. RESULTS: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between (99m)Tc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). CONCLUSION: Initial evidence suggests that (99m)Tc-TF could provide a non-invasive indicator of glioma proliferative activity.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Aneuploidy,Brain Neoplasms/genetics/*pathology/*radionuclide imaging,Cell Proliferation,DNA/genetics,Female,Flow Cytometry,Gamma Cameras,Glioblastoma/pathology/radionuclide imaging,Glioma/genetics/*pathology/*radionuclide imaging,Humans,Image Processing, Computer-Assisted,Male,Middle Aged,Organophosphorus Compounds/*diagnostic use,Organotechnetium Compounds/*diagnostic use,Pilot Projects,Prospective Studies,Radiopharmaceuticals/*diagnostic use,Tomography, Emission-Computed, Single-Photon
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22760
ISSN: 1872-6968
Link: http://www.ncbi.nlm.nih.gov/pubmed/19726126
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