Correlative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus (Journal article)

Moutsopoulos, H. M./ Klippel, J. H./ Pavlidis, N./ Wolf, R. O./ Sweet, J. B./ Steinberg, A. D./ Chu, F. C./ Tarpley, T. M.


We prospectively evaluated 24 patients with systemic lupus erythematosus for clinical, histologic, and serologic evidence of sicca syndrome. Abnormalties suggestive of sicca syndrome in patients with systemic lupus were identified by parotid scan (58%), questionnaire (54%), labial biopsy (50%), Schirmer's test (21%), and parotid flow rate (13%). An increased frequency of autoantibodies to gamma globulin and cellular antigen SS-A was detected in lupus patients with histologic changes on labial biopsy. The serologic findings are similar to those of patients with sicca syndrome alone with the exception of the reduced incidence of anti-SS-B in patients with systemic lupus.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Autoantibodies/*analysis,Female,Humans,Lupus Erythematosus, Systemic/*complications/immunology/pathology,Male,Middle Aged,Prospective Studies,Salivary Glands/*pathology,Salivary Glands, Minor/*pathology,Sjogren's Syndrome/*complications/immunology/pathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22750
ISSN: 0004-3591
Link: http://www.ncbi.nlm.nih.gov/pubmed/7352942
http://onlinelibrary.wiley.com/store/10.1002/art.1780230107/asset/1780230107_ftp.pdf?v=1&t=h0nibg54&s=f307fe867ecde2f8c30af212e7525ea4b1db14b1
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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