Cryosurgery during topical imiquimod: a successful combination modality for lentigo maligna (Journal article)

Bassukas, I. D./ Gamvroulia, C./ Zioga, A./ Nomikos, K./ Fotika, C.

BACKGROUND: Either cryosurgery or topical imiquimod have been used to treat patients with lentigo maligna in cases where surgery is not feasible. METHODS: We report a patient with lentigo maligna, who was treated with the combination of topical imiquimod and cryosurgery, and review the rationale, which led us to design the present combined cryo-immunological treatment modality. RESULTS: Sustained clearance of lentigo maligna to date (26 months after treatment). The successful treatment of this patient was based on the following rationale: A cryosurgery session during continuing imiquimod application may: (i) reinforce apoptosis of tumor cells; (ii) strengthen antiangiogenesis in the treated tumor; and (iii) build-up a potent tumor-destructive immune response by a cascade of events starting with imiquimod-promoted attraction of immature dendritic antigen-presenting cells (DCs) into the tumor. DCs further mature within the tumor-antigen-rich environment of subsequently cryo-destructed tumor and upon imiquimod-driven migration into the peripheral lymph nodes can stimulate a specific antineoplastic cell-mediated immunity. Finally, continuing imiquimod application after cryosurgery may increase recruitment of activated effector cells into the tumor tissue leading to its destruction. CONCLUSION: Cryosurgery during continued topical imiquimod seems to be a promising treatment for lentigo maligna.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adjuvants, Immunologic/*administration & dosage,Administration, Cutaneous,Aged,Aminoquinolines/*administration & dosage,Combined Modality Therapy,*Cryosurgery,Humans,Hutchinson's Melanotic Freckle/*therapy,Male,Skin Neoplasms/*therapy
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/22699
ISSN: 1365-4632
Link: http://www.ncbi.nlm.nih.gov/pubmed/18412875
http://onlinelibrary.wiley.com/store/10.1111/j.1365-4632.2008.03562.x/asset/j.1365-4632.2008.03562.x.pdf?v=1&t=h0oyore4&s=444775c337d4c4bcf39589144d89f782bfe7fc3b
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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